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Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)

Identifieur interne : 002D60 ( Main/Exploration ); précédent : 002D59; suivant : 002D61

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)

Auteurs : G. Davies [Royaume-Uni] ; N. Armstrong [Australie] ; J C Bis [États-Unis] ; J. Bressler [États-Unis] ; V. Chouraki [France, États-Unis] ; S. Giddaluru [Norvège] ; E. Hofer [Autriche] ; C A Ibrahim-Verbaas [Pays-Bas] ; M. Kirin [Royaume-Uni] ; J. Lahti [Finlande] ; S J Van Der Lee [Pays-Bas] ; S. Le Hellard [Norvège] ; T. Liu [Allemagne] ; R E Marioni [Royaume-Uni, Australie] ; C. Oldmeadow [Australie] ; I. Postmus [Pays-Bas] ; A V Smith [Islande] ; J A Smith [États-Unis] ; A. Thalamuthu [Australie] ; R. Thomson ; V. Vitart [Royaume-Uni] ; J. Wang [États-Unis] ; L. Yu [États-Unis] ; L. Zgaga [Irlande (pays), Croatie] ; W. Zhao [États-Unis] ; R. Boxall [Royaume-Uni] ; S E Harris [Royaume-Uni] ; W D Hill [Royaume-Uni] ; D C Liewald [Royaume-Uni] ; M. Luciano [Royaume-Uni] ; H. Adams [Pays-Bas] ; D. Ames [Australie] ; N. Amin [Pays-Bas] ; P. Amouyel [France] ; A A Assareh [Australie] ; R. Au [États-Unis] ; J T Becker [États-Unis] ; A. Beiser [États-Unis] ; C. Berr [France] ; L. Bertram [Allemagne, Royaume-Uni] ; E. Boerwinkle [États-Unis] ; B M Buckley [Irlande (pays)] ; H. Campbell [Royaume-Uni] ; J. Corley [Royaume-Uni] ; P L De Jager [États-Unis] ; C. Dufouil [France] ; J G Eriksson [Finlande] ; T. Espeseth [Norvège] ; J D Faul [États-Unis] ; I. Ford [Royaume-Uni] ; Generation Scotland [Royaume-Uni] ; R F Gottesman [États-Unis] ; M E Griswold [États-Unis] ; V. Gudnason [Islande] ; T B Harris [États-Unis] ; G. Heiss [États-Unis] ; A. Hofman [Pays-Bas] ; E G Holliday [Australie] ; J. Huffman [Royaume-Uni] ; S L R. Kardia [États-Unis] ; N. Kochan [Australie] ; D S Knopman [États-Unis] ; J B Kwok [Australie] ; J-C Lambert [France] ; T. Lee [Australie] ; G. Li [États-Unis] ; S-C Li [Allemagne] ; M. Loitfelder [Autriche] ; O L Lopez [États-Unis] ; A J Lundervold [Norvège] ; A. Lundqvist [Suède] ; K A Mather [Australie] ; S S Mirza [Pays-Bas] ; L. Nyberg [Suède] ; B A Oostra [Pays-Bas] ; A. Palotie [Royaume-Uni, Finlande] ; G. Papenberg [Allemagne, Suède] ; A. Pattie [Royaume-Uni] ; K. Petrovic [Autriche] ; O. Polasek [Croatie] ; B M Psaty [États-Unis] ; P. Redmond [Royaume-Uni] ; S. Reppermund [Australie] ; J I Rotter [États-Unis] ; H. Schmidt [Autriche] ; M. Schuur [Pays-Bas] ; P W Schofield [Australie] ; R J Scott [Australie] ; V M Steen [Norvège] ; D J Stott [Royaume-Uni] ; J C Van Swieten [Pays-Bas] ; K D Taylor [États-Unis] ; J. Trollor [Australie] ; S. Trompet [Pays-Bas] ; A G Uitterlinden [Pays-Bas] ; G. Weinstein [États-Unis] ; E. Widen [Finlande] ; B G Windham [États-Unis] ; J W Jukema [Pays-Bas] ; A F Wright [Royaume-Uni] ; M J Wright [Australie] ; Q. Yang [États-Unis] ; H. Amieva [France] ; J R Attia [Australie] ; D A Bennett [États-Unis] ; H. Brodaty [Australie] ; A J M. De Craen [Pays-Bas] ; C. Hayward [Royaume-Uni] ; M A Ikram [Pays-Bas] ; U. Lindenberger [Allemagne] ; L-G Nilsson [Suède] ; D J Porteous [Royaume-Uni] ; K. R Ikkönen [Finlande] ; I. Reinvang [Norvège] ; I. Rudan [Royaume-Uni] ; P S Sachdev [Australie] ; R. Schmidt [Autriche] ; P R Schofield [Australie] ; V. Srikanth [Australie] ; J M Starr [Royaume-Uni] ; S T Turner [États-Unis] ; D R Weir [États-Unis] ; J F Wilson [Royaume-Uni] ; C. Van Duijn [Pays-Bas] ; L. Launer [États-Unis] ; A L Fitzpatrick [États-Unis] ; S. Seshadri [États-Unis] ; T H Mosley [États-Unis] ; I J Deary [Royaume-Uni]

Source :

RBID : PMC:4356746

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English descriptors

Abstract

General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N=53 949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P=3.93 × 10−9, MIR2113; rs17522122, P=2.55 × 10−8, AKAP6; rs10119, P=5.67 × 10−9, APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P=1 × 10−6). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (N=6617) and the Health and Retirement Study (N=5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e.=5%) and 28% (s.e.=7%), respectively. Using polygenic prediction analysis, ~1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (N=5487; P=1.5 × 10−17). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease: TOMM40, APOE, ABCG1 and MEF2C.


Url:
DOI: 10.1038/mp.2014.188
PubMed: 25644384
PubMed Central: 4356746


Affiliations:

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Le document en format XML

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<name sortKey="Kirin, M" sort="Kirin, M" uniqKey="Kirin M" first="M" last="Kirin">M. Kirin</name>
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<institution>Folkhälsan Research Centre</institution>
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<country xml:lang="fr">Norvège</country>
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</nlm:aff>
<country xml:lang="fr">Norvège</country>
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<name sortKey="Liu, T" sort="Liu, T" uniqKey="Liu T" first="T" last="Liu">T. Liu</name>
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<institution>Max Planck Institute for Human Development</institution>
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<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<institution>Max Planck Institute for Molecular Genetics</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author>
<name sortKey="Marioni, R E" sort="Marioni, R E" uniqKey="Marioni R" first="R E" last="Marioni">R E Marioni</name>
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<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<nlm:aff id="aff20">
<institution>Queensland Brain Institute, The University of Queensland</institution>
, Brisbane, QLD,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author>
<name sortKey="Oldmeadow, C" sort="Oldmeadow, C" uniqKey="Oldmeadow C" first="C" last="Oldmeadow">C. Oldmeadow</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author>
<name sortKey="Postmus, I" sort="Postmus, I" uniqKey="Postmus I" first="I" last="Postmus">I. Postmus</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff23">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Smith, A V" sort="Smith, A V" uniqKey="Smith A" first="A V" last="Smith">A V Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="aff24">
<institution>Icelandic Heart Association</institution>
, Kopavogur,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff25">
<institution>University of Iceland</institution>
, Reykjavik,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<author>
<name sortKey="Smith, J A" sort="Smith, J A" uniqKey="Smith J" first="J A" last="Smith">J A Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<institution>Department of Epidemiology, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Thalamuthu, A" sort="Thalamuthu, A" uniqKey="Thalamuthu A" first="A" last="Thalamuthu">A. Thalamuthu</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Thomson, R" sort="Thomson, R" uniqKey="Thomson R" first="R" last="Thomson">R. Thomson</name>
<affiliation>
<nlm:aff id="aff28">
<institution>Menzies Research Institute</institution>
, Hobart,
<country>Tasmania</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Tasmania</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Vitart, V" sort="Vitart, V" uniqKey="Vitart V" first="V" last="Vitart">V. Vitart</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wang, J" sort="Wang, J" uniqKey="Wang J" first="J" last="Wang">J. Wang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff31">
<institution>Department of Biostatistics, Boston University School of Public Health</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yu, L" sort="Yu, L" uniqKey="Yu L" first="L" last="Yu">L. Yu</name>
<affiliation wicri:level="1">
<nlm:aff id="aff32">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, IL,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Zgaga, L" sort="Zgaga, L" uniqKey="Zgaga L" first="L" last="Zgaga">L. Zgaga</name>
<affiliation wicri:level="1">
<nlm:aff id="aff33">
<institution>Department of Public Health and Primary Care, Trinity College Dublin</institution>
, Dublin,
<country>Ireland</country>
</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff34">
<institution>Andrija Stampar School of Public Health, Medical School, University of Zagreb</institution>
, Zagreb,
<country>Croatia</country>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Zhao, W" sort="Zhao, W" uniqKey="Zhao W" first="W" last="Zhao">W. Zhao</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<institution>Department of Epidemiology, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Boxall, R" sort="Boxall, R" uniqKey="Boxall R" first="R" last="Boxall">R. Boxall</name>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Harris, S E" sort="Harris, S E" uniqKey="Harris S" first="S E" last="Harris">S E Harris</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hill, W D" sort="Hill, W D" uniqKey="Hill W" first="W D" last="Hill">W D Hill</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Liewald, D C" sort="Liewald, D C" uniqKey="Liewald D" first="D C" last="Liewald">D C Liewald</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Luciano, M" sort="Luciano, M" uniqKey="Luciano M" first="M" last="Luciano">M. Luciano</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Adams, H" sort="Adams, H" uniqKey="Adams H" first="H" last="Adams">H. Adams</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ames, D" sort="Ames, D" uniqKey="Ames D" first="D" last="Ames">D. Ames</name>
<affiliation wicri:level="1">
<nlm:aff id="aff37">
<institution>National Ageing Research Institute, Royal Melbourne Hospital</institution>
, Melbourne, VIC,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff38">
<institution>Academic Unit for Psychiatry of Old Age, St George's Hospital, University of Melbourne</institution>
, Kew,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amin, N" sort="Amin, N" uniqKey="Amin N" first="N" last="Amin">N. Amin</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amouyel, P" sort="Amouyel, P" uniqKey="Amouyel P" first="P" last="Amouyel">P. Amouyel</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Inserm-UMR744, Institut Pasteur de Lille, Unité d'Epidémiologie et de Santé Publique</institution>
, Lille,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Assareh, A A" sort="Assareh, A A" uniqKey="Assareh A" first="A A" last="Assareh">A A Assareh</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Au, R" sort="Au, R" uniqKey="Au R" first="R" last="Au">R. Au</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Becker, J T" sort="Becker, J T" uniqKey="Becker J" first="J T" last="Becker">J T Becker</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">
<institution>Department of Neurology, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff40">
<institution>Department of Psychiatry, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff41">
<institution>Department of Psychology, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Beiser, A" sort="Beiser, A" uniqKey="Beiser A" first="A" last="Beiser">A. Beiser</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Berr, C" sort="Berr, C" uniqKey="Berr C" first="C" last="Berr">C. Berr</name>
<affiliation wicri:level="1">
<nlm:aff id="aff42">
<institution>Inserm, U106</institution>
, Montpellier,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff43">
<institution>Université Montpellier I</institution>
, Montpellier,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bertram, L" sort="Bertram, L" uniqKey="Bertram L" first="L" last="Bertram">L. Bertram</name>
<affiliation wicri:level="1">
<nlm:aff id="aff18">
<institution>Max Planck Institute for Molecular Genetics</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff44">
<institution>Faculty of Medicine, School of Public Health, Imperial College</institution>
, London,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Boerwinkle, E" sort="Boerwinkle, E" uniqKey="Boerwinkle E" first="E" last="Boerwinkle">E. Boerwinkle</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<institution>Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston</institution>
, Houston, TX,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff45">
<institution>Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston</institution>
, Houston, TX,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff46">
<institution>Human Genome Sequencing Center, Baylor College of Medicine</institution>
, Houston, TX,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Buckley, B M" sort="Buckley, B M" uniqKey="Buckley B" first="B M" last="Buckley">B M Buckley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff47">
<institution>Department of Pharmacology and Therapeutics, University College Cork</institution>
, Cork,
<country>Ireland</country>
</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Campbell, H" sort="Campbell, H" uniqKey="Campbell H" first="H" last="Campbell">H. Campbell</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Corley, J" sort="Corley, J" uniqKey="Corley J" first="J" last="Corley">J. Corley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="De Jager, P L" sort="De Jager, P L" uniqKey="De Jager P" first="P L" last="De Jager">P L De Jager</name>
<affiliation wicri:level="1">
<nlm:aff id="aff48">
<institution>Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff49">
<institution>Harvard Medical School</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff50">
<institution>Program in Medical and Population Genetics, Broad Institute</institution>
, Cambridge, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dufouil, C" sort="Dufouil, C" uniqKey="Dufouil C" first="C" last="Dufouil">C. Dufouil</name>
<affiliation wicri:level="1">
<nlm:aff id="aff51">
<institution>Inserm U708, Neuroepidemiology</institution>
, Paris,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff52">
<institution>Inserm U897, Université Bordeaux Segalen</institution>
, Bordeaux,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Eriksson, J G" sort="Eriksson, J G" uniqKey="Eriksson J" first="J G" last="Eriksson">J G Eriksson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff16">
<institution>Folkhälsan Research Centre</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff53">
<institution>National Institute for Health and Welfare</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff54">
<institution>Department of General Practice and Primary health Care, University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff55">
<institution>Unit of General Practice, Helsinki University Central Hospital</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Espeseth, T" sort="Espeseth, T" uniqKey="Espeseth T" first="T" last="Espeseth">T. Espeseth</name>
<affiliation wicri:level="1">
<nlm:aff id="aff56">
<institution>K.G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo</institution>
, Oslo,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff57">
<institution>Department of Psychology, University of Oslo</institution>
, Oslo,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Faul, J D" sort="Faul, J D" uniqKey="Faul J" first="J D" last="Faul">J D Faul</name>
<affiliation wicri:level="1">
<nlm:aff id="aff58">
<institution>Survey Research Center, Institute for Social Research, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ford, I" sort="Ford, I" uniqKey="Ford I" first="I" last="Ford">I. Ford</name>
<affiliation wicri:level="1">
<nlm:aff id="aff59">
<institution>Robertson Center for Biostatistics</institution>
, Glasgow,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Scotland, Generation" sort="Scotland, Generation" uniqKey="Scotland G" first="Generation" last="Scotland">Generation Scotland</name>
<affiliation wicri:level="1">
<nlm:aff id="aff60">
<institution>Generation Scotland, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gottesman, R F" sort="Gottesman, R F" uniqKey="Gottesman R" first="R F" last="Gottesman">R F Gottesman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff61">
<institution>Department of Neurology, Johns Hopkins University School of Medicine</institution>
, Baltimore, MD,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Griswold, M E" sort="Griswold, M E" uniqKey="Griswold M" first="M E" last="Griswold">M E Griswold</name>
<affiliation wicri:level="1">
<nlm:aff id="aff62">
<institution>Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center</institution>
, Jackson, MS,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gudnason, V" sort="Gudnason, V" uniqKey="Gudnason V" first="V" last="Gudnason">V. Gudnason</name>
<affiliation wicri:level="1">
<nlm:aff id="aff24">
<institution>Icelandic Heart Association</institution>
, Kopavogur,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff25">
<institution>University of Iceland</institution>
, Reykjavik,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Harris, T B" sort="Harris, T B" uniqKey="Harris T" first="T B" last="Harris">T B Harris</name>
<affiliation wicri:level="1">
<nlm:aff id="aff63">
<institution>Intramural Research Program National Institutes on Aging, National Institutes of Health</institution>
, Bethesda, MD,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Heiss, G" sort="Heiss, G" uniqKey="Heiss G" first="G" last="Heiss">G. Heiss</name>
<affiliation wicri:level="1">
<nlm:aff id="aff64">
<institution>Department of Epidemiology, University of North Carolina Gillings School of Global Public Health</institution>
, Chapel Hill, NC,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hofman, A" sort="Hofman, A" uniqKey="Hofman A" first="A" last="Hofman">A. Hofman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Holliday, E G" sort="Holliday, E G" uniqKey="Holliday E" first="E G" last="Holliday">E G Holliday</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Huffman, J" sort="Huffman, J" uniqKey="Huffman J" first="J" last="Huffman">J. Huffman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kardia, S L R" sort="Kardia, S L R" uniqKey="Kardia S" first="S L R" last="Kardia">S L R. Kardia</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<institution>Department of Epidemiology, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kochan, N" sort="Kochan, N" uniqKey="Kochan N" first="N" last="Kochan">N. Kochan</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff65">
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Knopman, D S" sort="Knopman, D S" uniqKey="Knopman D" first="D S" last="Knopman">D S Knopman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff66">
<institution>Department of Neurology, Mayo Clinic</institution>
, Rochester, MN,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kwok, J B" sort="Kwok, J B" uniqKey="Kwok J" first="J B" last="Kwok">J B Kwok</name>
<affiliation wicri:level="1">
<nlm:aff id="aff67">
<institution>Neuroscience Research Australia</institution>
, Randwick, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff68">
<institution>School of Medical Sciences, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lambert, J C" sort="Lambert, J C" uniqKey="Lambert J" first="J-C" last="Lambert">J-C Lambert</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Inserm-UMR744, Institut Pasteur de Lille, Unité d'Epidémiologie et de Santé Publique</institution>
, Lille,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lee, T" sort="Lee, T" uniqKey="Lee T" first="T" last="Lee">T. Lee</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff65">
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Li, G" sort="Li, G" uniqKey="Li G" first="G" last="Li">G. Li</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Li, S C" sort="Li, S C" uniqKey="Li S" first="S-C" last="Li">S-C Li</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff69">
<institution>Technische Universität Dresden</institution>
, Dresden,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Loitfelder, M" sort="Loitfelder, M" uniqKey="Loitfelder M" first="M" last="Loitfelder">M. Loitfelder</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lopez, O L" sort="Lopez, O L" uniqKey="Lopez O" first="O L" last="Lopez">O L Lopez</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">
<institution>Department of Neurology, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lundervold, A J" sort="Lundervold, A J" uniqKey="Lundervold A" first="A J" last="Lundervold">A J Lundervold</name>
<affiliation wicri:level="1">
<nlm:aff id="aff70">
<institution>Department of Biological and Medical Psychology, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff71">
<institution>Kavli Research Centre for Aging and Dementia, Haraldsplass Deaconess Hospital</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff72">
<institution>K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lundqvist, A" sort="Lundqvist, A" uniqKey="Lundqvist A" first="A" last="Lundqvist">A. Lundqvist</name>
<affiliation wicri:level="1">
<nlm:aff id="aff73">
<institution>Umeå Center for Functional Brain Imaging (UFBI), Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mather, K A" sort="Mather, K A" uniqKey="Mather K" first="K A" last="Mather">K A Mather</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mirza, S S" sort="Mirza, S S" uniqKey="Mirza S" first="S S" last="Mirza">S S Mirza</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Nyberg, L" sort="Nyberg, L" uniqKey="Nyberg L" first="L" last="Nyberg">L. Nyberg</name>
<affiliation wicri:level="1">
<nlm:aff id="aff73">
<institution>Umeå Center for Functional Brain Imaging (UFBI), Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff74">
<institution>Department of Radiation Sciences, Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff75">
<institution>Department of Integrative Medical Biology, Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Oostra, B A" sort="Oostra, B A" uniqKey="Oostra B" first="B A" last="Oostra">B A Oostra</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Palotie, A" sort="Palotie, A" uniqKey="Palotie A" first="A" last="Palotie">A. Palotie</name>
<affiliation wicri:level="1">
<nlm:aff id="aff76">
<institution>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus</institution>
, Cambridge,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff77">
<institution>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff78">
<institution>Department of Medical Genetics, University of Helsinki and University Central Hospital</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Papenberg, G" sort="Papenberg, G" uniqKey="Papenberg G" first="G" last="Papenberg">G. Papenberg</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff79">
<institution>Karolinska Institutet, Aging Research Center, Stockholm University</institution>
, Stockholm,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pattie, A" sort="Pattie, A" uniqKey="Pattie A" first="A" last="Pattie">A. Pattie</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Petrovic, K" sort="Petrovic, K" uniqKey="Petrovic K" first="K" last="Petrovic">K. Petrovic</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Polasek, O" sort="Polasek, O" uniqKey="Polasek O" first="O" last="Polasek">O. Polasek</name>
<affiliation wicri:level="1">
<nlm:aff id="aff80">
<institution>Faculty of Medicine, Department of Public Health, University of Split</institution>
, Split,
<country>Croatia</country>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Psaty, B M" sort="Psaty, B M" uniqKey="Psaty B" first="B M" last="Psaty">B M Psaty</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff81">
<institution>Deparment of Epidemiology, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff82">
<institution>Deparment of Health Services, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff83">
<institution>Group Health Research Unit, Group Health Cooperative</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Redmond, P" sort="Redmond, P" uniqKey="Redmond P" first="P" last="Redmond">P. Redmond</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Reppermund, S" sort="Reppermund, S" uniqKey="Reppermund S" first="S" last="Reppermund">S. Reppermund</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rotter, J I" sort="Rotter, J I" uniqKey="Rotter J" first="J I" last="Rotter">J I Rotter</name>
<affiliation wicri:level="1">
<nlm:aff id="aff84">
<institution>Institute for Translational Genomics and Population Sciences Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff85">
<institution>Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, H" sort="Schmidt, H" uniqKey="Schmidt H" first="H" last="Schmidt">H. Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff86">
<institution>Centre for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schuur, M" sort="Schuur, M" uniqKey="Schuur M" first="M" last="Schuur">M. Schuur</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Department of Neurology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schofield, P W" sort="Schofield, P W" uniqKey="Schofield P" first="P W" last="Schofield">P W Schofield</name>
<affiliation wicri:level="1">
<nlm:aff id="aff87">
<institution>School of Medicine and Public Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Scott, R J" sort="Scott, R J" uniqKey="Scott R" first="R J" last="Scott">R J Scott</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Steen, V M" sort="Steen, V M" uniqKey="Steen V" first="V M" last="Steen">V M Steen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<institution>K.G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff9">
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Stott, D J" sort="Stott, D J" uniqKey="Stott D" first="D J" last="Stott">D J Stott</name>
<affiliation wicri:level="1">
<nlm:aff id="aff88">
<institution>Institute of Cardiovascular and Medical Sciences, University of Glasgow</institution>
, Glasgow,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Swieten, J C" sort="Van Swieten, J C" uniqKey="Van Swieten J" first="J C" last="Van Swieten">J C Van Swieten</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Department of Neurology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Taylor, K D" sort="Taylor, K D" uniqKey="Taylor K" first="K D" last="Taylor">K D Taylor</name>
<affiliation wicri:level="1">
<nlm:aff id="aff84">
<institution>Institute for Translational Genomics and Population Sciences Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff89">
<institution>Department of Pediatrics, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Trollor, J" sort="Trollor, J" uniqKey="Trollor J" first="J" last="Trollor">J. Trollor</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff90">
<institution>Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Trompet, S" sort="Trompet, S" uniqKey="Trompet S" first="S" last="Trompet">S. Trompet</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff91">
<institution>Department of Cardiology, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Uitterlinden, A G" sort="Uitterlinden, A G" uniqKey="Uitterlinden A" first="A G" last="Uitterlinden">A G Uitterlinden</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff92">
<institution>Department of Internal Medicine, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Weinstein, G" sort="Weinstein, G" uniqKey="Weinstein G" first="G" last="Weinstein">G. Weinstein</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Widen, E" sort="Widen, E" uniqKey="Widen E" first="E" last="Widen">E. Widen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff77">
<institution>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Windham, B G" sort="Windham, B G" uniqKey="Windham B" first="B G" last="Windham">B G Windham</name>
<affiliation wicri:level="1">
<nlm:aff id="aff93">
<institution>Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, MS,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jukema, J W" sort="Jukema, J W" uniqKey="Jukema J" first="J W" last="Jukema">J W Jukema</name>
<affiliation wicri:level="1">
<nlm:aff id="aff91">
<institution>Department of Cardiology, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff94">
<institution>Durrer Center for Cardiogenetic Research</institution>
, Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff95">
<institution>Interuniversity Cardiology Institute of the Netherlands</institution>
, Utrecht,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wright, A F" sort="Wright, A F" uniqKey="Wright A" first="A F" last="Wright">A F Wright</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wright, M J" sort="Wright, M J" uniqKey="Wright M" first="M J" last="Wright">M J Wright</name>
<affiliation wicri:level="1">
<nlm:aff id="aff96">
<institution>Neuroimaging Genetics Group, QIMR Berghofer Medical Research Institute</institution>
, Brisbane, QLD,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yang, Q" sort="Yang, Q" uniqKey="Yang Q" first="Q" last="Yang">Q. Yang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff31">
<institution>Department of Biostatistics, Boston University School of Public Health</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amieva, H" sort="Amieva, H" uniqKey="Amieva H" first="H" last="Amieva">H. Amieva</name>
<affiliation wicri:level="1">
<nlm:aff id="aff52">
<institution>Inserm U897, Université Bordeaux Segalen</institution>
, Bordeaux,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Attia, J R" sort="Attia, J R" uniqKey="Attia J" first="J R" last="Attia">J R Attia</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bennett, D A" sort="Bennett, D A" uniqKey="Bennett D" first="D A" last="Bennett">D A Bennett</name>
<affiliation wicri:level="1">
<nlm:aff id="aff32">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, IL,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Brodaty, H" sort="Brodaty, H" uniqKey="Brodaty H" first="H" last="Brodaty">H. Brodaty</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff97">
<institution>Dementia Collaborative Research Centre, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="De Craen, A J M" sort="De Craen, A J M" uniqKey="De Craen A" first="A J M" last="De Craen">A J M. De Craen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff23">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hayward, C" sort="Hayward, C" uniqKey="Hayward C" first="C" last="Hayward">C. Hayward</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ikram, M A" sort="Ikram, M A" uniqKey="Ikram M" first="M A" last="Ikram">M A Ikram</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Department of Neurology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff98">
<institution>Department of Radiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lindenberger, U" sort="Lindenberger, U" uniqKey="Lindenberger U" first="U" last="Lindenberger">U. Lindenberger</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Nilsson, L G" sort="Nilsson, L G" uniqKey="Nilsson L" first="L-G" last="Nilsson">L-G Nilsson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff99">
<institution>ARC, Karolinska Institutet, Stockholm and UFBI, Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Porteous, D J" sort="Porteous, D J" uniqKey="Porteous D" first="D J" last="Porteous">D J Porteous</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff60">
<institution>Generation Scotland, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="R Ikkonen, K" sort="R Ikkonen, K" uniqKey="R Ikkonen K" first="K" last="R Ikkönen">K. R Ikkönen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">
<institution>Institute of Behavioural Sciences, University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Reinvang, I" sort="Reinvang, I" uniqKey="Reinvang I" first="I" last="Reinvang">I. Reinvang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff57">
<institution>Department of Psychology, University of Oslo</institution>
, Oslo,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rudan, I" sort="Rudan, I" uniqKey="Rudan I" first="I" last="Rudan">I. Rudan</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sachdev, P S" sort="Sachdev, P S" uniqKey="Sachdev P" first="P S" last="Sachdev">P S Sachdev</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff65">
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, R" sort="Schmidt, R" uniqKey="Schmidt R" first="R" last="Schmidt">R. Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schofield, P R" sort="Schofield, P R" uniqKey="Schofield P" first="P R" last="Schofield">P R Schofield</name>
<affiliation wicri:level="1">
<nlm:aff id="aff100">
<institution>Neuroscience Research Australia</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff101">
<institution>Faculty of Medicine, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Srikanth, V" sort="Srikanth, V" uniqKey="Srikanth V" first="V" last="Srikanth">V. Srikanth</name>
<affiliation>
<nlm:aff id="aff28">
<institution>Menzies Research Institute</institution>
, Hobart,
<country>Tasmania</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Tasmania</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff102">
<institution>Stroke and Ageing Research, Medicine, Southern Clinical School, Monash University</institution>
, Melbourne, VIC,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Starr, J M" sort="Starr, J M" uniqKey="Starr J" first="J M" last="Starr">J M Starr</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff103">
<institution>Alzheimer Scotland Dementia Research Centre, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Turner, S T" sort="Turner, S T" uniqKey="Turner S" first="S T" last="Turner">S T Turner</name>
<affiliation wicri:level="1">
<nlm:aff id="aff104">
<institution>Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic</institution>
, Rochester, MN,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Weir, D R" sort="Weir, D R" uniqKey="Weir D" first="D R" last="Weir">D R Weir</name>
<affiliation wicri:level="1">
<nlm:aff id="aff58">
<institution>Survey Research Center, Institute for Social Research, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wilson, J F" sort="Wilson, J F" uniqKey="Wilson J" first="J F" last="Wilson">J F Wilson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Duijn, C" sort="Van Duijn, C" uniqKey="Van Duijn C" first="C" last="Van Duijn">C. Van Duijn</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Launer, L" sort="Launer, L" uniqKey="Launer L" first="L" last="Launer">L. Launer</name>
<affiliation wicri:level="1">
<nlm:aff id="aff63">
<institution>Intramural Research Program National Institutes on Aging, National Institutes of Health</institution>
, Bethesda, MD,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fitzpatrick, A L" sort="Fitzpatrick, A L" uniqKey="Fitzpatrick A" first="A L" last="Fitzpatrick">A L Fitzpatrick</name>
<affiliation wicri:level="1">
<nlm:aff id="aff81">
<institution>Deparment of Epidemiology, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff105">
<institution>Department of Global Health, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Seshadri, S" sort="Seshadri, S" uniqKey="Seshadri S" first="S" last="Seshadri">S. Seshadri</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mosley, T H" sort="Mosley, T H" uniqKey="Mosley T" first="T H" last="Mosley">T H Mosley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff93">
<institution>Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, MS,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Deary, I J" sort="Deary, I J" uniqKey="Deary I" first="I J" last="Deary">I J Deary</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
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<title xml:lang="en" level="a" type="main">Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (
<italic>N</italic>
=53 949)</title>
<author>
<name sortKey="Davies, G" sort="Davies, G" uniqKey="Davies G" first="G" last="Davies">G. Davies</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Armstrong, N" sort="Armstrong, N" uniqKey="Armstrong N" first="N" last="Armstrong">N. Armstrong</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<institution>School of Mathematics and Statistics, University of Sydney</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bis, J C" sort="Bis, J C" uniqKey="Bis J" first="J C" last="Bis">J C Bis</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bressler, J" sort="Bressler, J" uniqKey="Bressler J" first="J" last="Bressler">J. Bressler</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<institution>Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston</institution>
, Houston, TX,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Chouraki, V" sort="Chouraki, V" uniqKey="Chouraki V" first="V" last="Chouraki">V. Chouraki</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Inserm-UMR744, Institut Pasteur de Lille, Unité d'Epidémiologie et de Santé Publique</institution>
, Lille,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Giddaluru, S" sort="Giddaluru, S" uniqKey="Giddaluru S" first="S" last="Giddaluru">S. Giddaluru</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<institution>K.G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff9">
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hofer, E" sort="Hofer, E" uniqKey="Hofer E" first="E" last="Hofer">E. Hofer</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff11">
<institution>Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ibrahim Verbaas, C A" sort="Ibrahim Verbaas, C A" uniqKey="Ibrahim Verbaas C" first="C A" last="Ibrahim-Verbaas">C A Ibrahim-Verbaas</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Department of Neurology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kirin, M" sort="Kirin, M" uniqKey="Kirin M" first="M" last="Kirin">M. Kirin</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lahti, J" sort="Lahti, J" uniqKey="Lahti J" first="J" last="Lahti">J. Lahti</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">
<institution>Institute of Behavioural Sciences, University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff16">
<institution>Folkhälsan Research Centre</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Der Lee, S J" sort="Van Der Lee, S J" uniqKey="Van Der Lee S" first="S J" last="Van Der Lee">S J Van Der Lee</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Le Hellard, S" sort="Le Hellard, S" uniqKey="Le Hellard S" first="S" last="Le Hellard">S. Le Hellard</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<institution>K.G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff9">
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Liu, T" sort="Liu, T" uniqKey="Liu T" first="T" last="Liu">T. Liu</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff18">
<institution>Max Planck Institute for Molecular Genetics</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Marioni, R E" sort="Marioni, R E" uniqKey="Marioni R" first="R E" last="Marioni">R E Marioni</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff20">
<institution>Queensland Brain Institute, The University of Queensland</institution>
, Brisbane, QLD,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Oldmeadow, C" sort="Oldmeadow, C" uniqKey="Oldmeadow C" first="C" last="Oldmeadow">C. Oldmeadow</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Postmus, I" sort="Postmus, I" uniqKey="Postmus I" first="I" last="Postmus">I. Postmus</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff23">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Smith, A V" sort="Smith, A V" uniqKey="Smith A" first="A V" last="Smith">A V Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="aff24">
<institution>Icelandic Heart Association</institution>
, Kopavogur,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff25">
<institution>University of Iceland</institution>
, Reykjavik,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Smith, J A" sort="Smith, J A" uniqKey="Smith J" first="J A" last="Smith">J A Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<institution>Department of Epidemiology, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Thalamuthu, A" sort="Thalamuthu, A" uniqKey="Thalamuthu A" first="A" last="Thalamuthu">A. Thalamuthu</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Thomson, R" sort="Thomson, R" uniqKey="Thomson R" first="R" last="Thomson">R. Thomson</name>
<affiliation>
<nlm:aff id="aff28">
<institution>Menzies Research Institute</institution>
, Hobart,
<country>Tasmania</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Tasmania</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Vitart, V" sort="Vitart, V" uniqKey="Vitart V" first="V" last="Vitart">V. Vitart</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wang, J" sort="Wang, J" uniqKey="Wang J" first="J" last="Wang">J. Wang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff31">
<institution>Department of Biostatistics, Boston University School of Public Health</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yu, L" sort="Yu, L" uniqKey="Yu L" first="L" last="Yu">L. Yu</name>
<affiliation wicri:level="1">
<nlm:aff id="aff32">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, IL,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Zgaga, L" sort="Zgaga, L" uniqKey="Zgaga L" first="L" last="Zgaga">L. Zgaga</name>
<affiliation wicri:level="1">
<nlm:aff id="aff33">
<institution>Department of Public Health and Primary Care, Trinity College Dublin</institution>
, Dublin,
<country>Ireland</country>
</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff34">
<institution>Andrija Stampar School of Public Health, Medical School, University of Zagreb</institution>
, Zagreb,
<country>Croatia</country>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Zhao, W" sort="Zhao, W" uniqKey="Zhao W" first="W" last="Zhao">W. Zhao</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<institution>Department of Epidemiology, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Boxall, R" sort="Boxall, R" uniqKey="Boxall R" first="R" last="Boxall">R. Boxall</name>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Harris, S E" sort="Harris, S E" uniqKey="Harris S" first="S E" last="Harris">S E Harris</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hill, W D" sort="Hill, W D" uniqKey="Hill W" first="W D" last="Hill">W D Hill</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Liewald, D C" sort="Liewald, D C" uniqKey="Liewald D" first="D C" last="Liewald">D C Liewald</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Luciano, M" sort="Luciano, M" uniqKey="Luciano M" first="M" last="Luciano">M. Luciano</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Adams, H" sort="Adams, H" uniqKey="Adams H" first="H" last="Adams">H. Adams</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ames, D" sort="Ames, D" uniqKey="Ames D" first="D" last="Ames">D. Ames</name>
<affiliation wicri:level="1">
<nlm:aff id="aff37">
<institution>National Ageing Research Institute, Royal Melbourne Hospital</institution>
, Melbourne, VIC,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff38">
<institution>Academic Unit for Psychiatry of Old Age, St George's Hospital, University of Melbourne</institution>
, Kew,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amin, N" sort="Amin, N" uniqKey="Amin N" first="N" last="Amin">N. Amin</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amouyel, P" sort="Amouyel, P" uniqKey="Amouyel P" first="P" last="Amouyel">P. Amouyel</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Inserm-UMR744, Institut Pasteur de Lille, Unité d'Epidémiologie et de Santé Publique</institution>
, Lille,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Assareh, A A" sort="Assareh, A A" uniqKey="Assareh A" first="A A" last="Assareh">A A Assareh</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Au, R" sort="Au, R" uniqKey="Au R" first="R" last="Au">R. Au</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Becker, J T" sort="Becker, J T" uniqKey="Becker J" first="J T" last="Becker">J T Becker</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">
<institution>Department of Neurology, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff40">
<institution>Department of Psychiatry, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff41">
<institution>Department of Psychology, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Beiser, A" sort="Beiser, A" uniqKey="Beiser A" first="A" last="Beiser">A. Beiser</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Berr, C" sort="Berr, C" uniqKey="Berr C" first="C" last="Berr">C. Berr</name>
<affiliation wicri:level="1">
<nlm:aff id="aff42">
<institution>Inserm, U106</institution>
, Montpellier,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff43">
<institution>Université Montpellier I</institution>
, Montpellier,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bertram, L" sort="Bertram, L" uniqKey="Bertram L" first="L" last="Bertram">L. Bertram</name>
<affiliation wicri:level="1">
<nlm:aff id="aff18">
<institution>Max Planck Institute for Molecular Genetics</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff44">
<institution>Faculty of Medicine, School of Public Health, Imperial College</institution>
, London,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Boerwinkle, E" sort="Boerwinkle, E" uniqKey="Boerwinkle E" first="E" last="Boerwinkle">E. Boerwinkle</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<institution>Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston</institution>
, Houston, TX,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff45">
<institution>Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston</institution>
, Houston, TX,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff46">
<institution>Human Genome Sequencing Center, Baylor College of Medicine</institution>
, Houston, TX,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Buckley, B M" sort="Buckley, B M" uniqKey="Buckley B" first="B M" last="Buckley">B M Buckley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff47">
<institution>Department of Pharmacology and Therapeutics, University College Cork</institution>
, Cork,
<country>Ireland</country>
</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Campbell, H" sort="Campbell, H" uniqKey="Campbell H" first="H" last="Campbell">H. Campbell</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Corley, J" sort="Corley, J" uniqKey="Corley J" first="J" last="Corley">J. Corley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="De Jager, P L" sort="De Jager, P L" uniqKey="De Jager P" first="P L" last="De Jager">P L De Jager</name>
<affiliation wicri:level="1">
<nlm:aff id="aff48">
<institution>Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff49">
<institution>Harvard Medical School</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff50">
<institution>Program in Medical and Population Genetics, Broad Institute</institution>
, Cambridge, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dufouil, C" sort="Dufouil, C" uniqKey="Dufouil C" first="C" last="Dufouil">C. Dufouil</name>
<affiliation wicri:level="1">
<nlm:aff id="aff51">
<institution>Inserm U708, Neuroepidemiology</institution>
, Paris,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff52">
<institution>Inserm U897, Université Bordeaux Segalen</institution>
, Bordeaux,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Eriksson, J G" sort="Eriksson, J G" uniqKey="Eriksson J" first="J G" last="Eriksson">J G Eriksson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff16">
<institution>Folkhälsan Research Centre</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff53">
<institution>National Institute for Health and Welfare</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff54">
<institution>Department of General Practice and Primary health Care, University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff55">
<institution>Unit of General Practice, Helsinki University Central Hospital</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Espeseth, T" sort="Espeseth, T" uniqKey="Espeseth T" first="T" last="Espeseth">T. Espeseth</name>
<affiliation wicri:level="1">
<nlm:aff id="aff56">
<institution>K.G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo</institution>
, Oslo,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff57">
<institution>Department of Psychology, University of Oslo</institution>
, Oslo,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Faul, J D" sort="Faul, J D" uniqKey="Faul J" first="J D" last="Faul">J D Faul</name>
<affiliation wicri:level="1">
<nlm:aff id="aff58">
<institution>Survey Research Center, Institute for Social Research, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ford, I" sort="Ford, I" uniqKey="Ford I" first="I" last="Ford">I. Ford</name>
<affiliation wicri:level="1">
<nlm:aff id="aff59">
<institution>Robertson Center for Biostatistics</institution>
, Glasgow,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Scotland, Generation" sort="Scotland, Generation" uniqKey="Scotland G" first="Generation" last="Scotland">Generation Scotland</name>
<affiliation wicri:level="1">
<nlm:aff id="aff60">
<institution>Generation Scotland, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gottesman, R F" sort="Gottesman, R F" uniqKey="Gottesman R" first="R F" last="Gottesman">R F Gottesman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff61">
<institution>Department of Neurology, Johns Hopkins University School of Medicine</institution>
, Baltimore, MD,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Griswold, M E" sort="Griswold, M E" uniqKey="Griswold M" first="M E" last="Griswold">M E Griswold</name>
<affiliation wicri:level="1">
<nlm:aff id="aff62">
<institution>Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center</institution>
, Jackson, MS,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Gudnason, V" sort="Gudnason, V" uniqKey="Gudnason V" first="V" last="Gudnason">V. Gudnason</name>
<affiliation wicri:level="1">
<nlm:aff id="aff24">
<institution>Icelandic Heart Association</institution>
, Kopavogur,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff25">
<institution>University of Iceland</institution>
, Reykjavik,
<country>Iceland</country>
</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Harris, T B" sort="Harris, T B" uniqKey="Harris T" first="T B" last="Harris">T B Harris</name>
<affiliation wicri:level="1">
<nlm:aff id="aff63">
<institution>Intramural Research Program National Institutes on Aging, National Institutes of Health</institution>
, Bethesda, MD,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Heiss, G" sort="Heiss, G" uniqKey="Heiss G" first="G" last="Heiss">G. Heiss</name>
<affiliation wicri:level="1">
<nlm:aff id="aff64">
<institution>Department of Epidemiology, University of North Carolina Gillings School of Global Public Health</institution>
, Chapel Hill, NC,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hofman, A" sort="Hofman, A" uniqKey="Hofman A" first="A" last="Hofman">A. Hofman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Holliday, E G" sort="Holliday, E G" uniqKey="Holliday E" first="E G" last="Holliday">E G Holliday</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Huffman, J" sort="Huffman, J" uniqKey="Huffman J" first="J" last="Huffman">J. Huffman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kardia, S L R" sort="Kardia, S L R" uniqKey="Kardia S" first="S L R" last="Kardia">S L R. Kardia</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">
<institution>Department of Epidemiology, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kochan, N" sort="Kochan, N" uniqKey="Kochan N" first="N" last="Kochan">N. Kochan</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff65">
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Knopman, D S" sort="Knopman, D S" uniqKey="Knopman D" first="D S" last="Knopman">D S Knopman</name>
<affiliation wicri:level="1">
<nlm:aff id="aff66">
<institution>Department of Neurology, Mayo Clinic</institution>
, Rochester, MN,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kwok, J B" sort="Kwok, J B" uniqKey="Kwok J" first="J B" last="Kwok">J B Kwok</name>
<affiliation wicri:level="1">
<nlm:aff id="aff67">
<institution>Neuroscience Research Australia</institution>
, Randwick, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff68">
<institution>School of Medical Sciences, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lambert, J C" sort="Lambert, J C" uniqKey="Lambert J" first="J-C" last="Lambert">J-C Lambert</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<institution>Inserm-UMR744, Institut Pasteur de Lille, Unité d'Epidémiologie et de Santé Publique</institution>
, Lille,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lee, T" sort="Lee, T" uniqKey="Lee T" first="T" last="Lee">T. Lee</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff65">
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Li, G" sort="Li, G" uniqKey="Li G" first="G" last="Li">G. Li</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Li, S C" sort="Li, S C" uniqKey="Li S" first="S-C" last="Li">S-C Li</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff69">
<institution>Technische Universität Dresden</institution>
, Dresden,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Loitfelder, M" sort="Loitfelder, M" uniqKey="Loitfelder M" first="M" last="Loitfelder">M. Loitfelder</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lopez, O L" sort="Lopez, O L" uniqKey="Lopez O" first="O L" last="Lopez">O L Lopez</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">
<institution>Department of Neurology, University of Pittsburgh</institution>
, Pittsburgh, PA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lundervold, A J" sort="Lundervold, A J" uniqKey="Lundervold A" first="A J" last="Lundervold">A J Lundervold</name>
<affiliation wicri:level="1">
<nlm:aff id="aff70">
<institution>Department of Biological and Medical Psychology, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff71">
<institution>Kavli Research Centre for Aging and Dementia, Haraldsplass Deaconess Hospital</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff72">
<institution>K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lundqvist, A" sort="Lundqvist, A" uniqKey="Lundqvist A" first="A" last="Lundqvist">A. Lundqvist</name>
<affiliation wicri:level="1">
<nlm:aff id="aff73">
<institution>Umeå Center for Functional Brain Imaging (UFBI), Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mather, K A" sort="Mather, K A" uniqKey="Mather K" first="K A" last="Mather">K A Mather</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mirza, S S" sort="Mirza, S S" uniqKey="Mirza S" first="S S" last="Mirza">S S Mirza</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Nyberg, L" sort="Nyberg, L" uniqKey="Nyberg L" first="L" last="Nyberg">L. Nyberg</name>
<affiliation wicri:level="1">
<nlm:aff id="aff73">
<institution>Umeå Center for Functional Brain Imaging (UFBI), Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff74">
<institution>Department of Radiation Sciences, Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff75">
<institution>Department of Integrative Medical Biology, Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Oostra, B A" sort="Oostra, B A" uniqKey="Oostra B" first="B A" last="Oostra">B A Oostra</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Palotie, A" sort="Palotie, A" uniqKey="Palotie A" first="A" last="Palotie">A. Palotie</name>
<affiliation wicri:level="1">
<nlm:aff id="aff76">
<institution>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus</institution>
, Cambridge,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff77">
<institution>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff78">
<institution>Department of Medical Genetics, University of Helsinki and University Central Hospital</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Papenberg, G" sort="Papenberg, G" uniqKey="Papenberg G" first="G" last="Papenberg">G. Papenberg</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff79">
<institution>Karolinska Institutet, Aging Research Center, Stockholm University</institution>
, Stockholm,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Pattie, A" sort="Pattie, A" uniqKey="Pattie A" first="A" last="Pattie">A. Pattie</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Petrovic, K" sort="Petrovic, K" uniqKey="Petrovic K" first="K" last="Petrovic">K. Petrovic</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Polasek, O" sort="Polasek, O" uniqKey="Polasek O" first="O" last="Polasek">O. Polasek</name>
<affiliation wicri:level="1">
<nlm:aff id="aff80">
<institution>Faculty of Medicine, Department of Public Health, University of Split</institution>
, Split,
<country>Croatia</country>
</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Psaty, B M" sort="Psaty, B M" uniqKey="Psaty B" first="B M" last="Psaty">B M Psaty</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<institution>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff81">
<institution>Deparment of Epidemiology, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff82">
<institution>Deparment of Health Services, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff83">
<institution>Group Health Research Unit, Group Health Cooperative</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Redmond, P" sort="Redmond, P" uniqKey="Redmond P" first="P" last="Redmond">P. Redmond</name>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Reppermund, S" sort="Reppermund, S" uniqKey="Reppermund S" first="S" last="Reppermund">S. Reppermund</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rotter, J I" sort="Rotter, J I" uniqKey="Rotter J" first="J I" last="Rotter">J I Rotter</name>
<affiliation wicri:level="1">
<nlm:aff id="aff84">
<institution>Institute for Translational Genomics and Population Sciences Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff85">
<institution>Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, H" sort="Schmidt, H" uniqKey="Schmidt H" first="H" last="Schmidt">H. Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff86">
<institution>Centre for Molecular Medicine, Institute of Molecular Biology and Biochemistry, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schuur, M" sort="Schuur, M" uniqKey="Schuur M" first="M" last="Schuur">M. Schuur</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Department of Neurology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schofield, P W" sort="Schofield, P W" uniqKey="Schofield P" first="P W" last="Schofield">P W Schofield</name>
<affiliation wicri:level="1">
<nlm:aff id="aff87">
<institution>School of Medicine and Public Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Scott, R J" sort="Scott, R J" uniqKey="Scott R" first="R J" last="Scott">R J Scott</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Steen, V M" sort="Steen, V M" uniqKey="Steen V" first="V M" last="Steen">V M Steen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<institution>K.G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff9">
<institution>Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>
, Bergen,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Stott, D J" sort="Stott, D J" uniqKey="Stott D" first="D J" last="Stott">D J Stott</name>
<affiliation wicri:level="1">
<nlm:aff id="aff88">
<institution>Institute of Cardiovascular and Medical Sciences, University of Glasgow</institution>
, Glasgow,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Swieten, J C" sort="Van Swieten, J C" uniqKey="Van Swieten J" first="J C" last="Van Swieten">J C Van Swieten</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Department of Neurology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Taylor, K D" sort="Taylor, K D" uniqKey="Taylor K" first="K D" last="Taylor">K D Taylor</name>
<affiliation wicri:level="1">
<nlm:aff id="aff84">
<institution>Institute for Translational Genomics and Population Sciences Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff89">
<institution>Department of Pediatrics, Harbor-UCLA Medical Center</institution>
, Los Angeles, CA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Trollor, J" sort="Trollor, J" uniqKey="Trollor J" first="J" last="Trollor">J. Trollor</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff90">
<institution>Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Trompet, S" sort="Trompet, S" uniqKey="Trompet S" first="S" last="Trompet">S. Trompet</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff91">
<institution>Department of Cardiology, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Uitterlinden, A G" sort="Uitterlinden, A G" uniqKey="Uitterlinden A" first="A G" last="Uitterlinden">A G Uitterlinden</name>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff92">
<institution>Department of Internal Medicine, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Weinstein, G" sort="Weinstein, G" uniqKey="Weinstein G" first="G" last="Weinstein">G. Weinstein</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Widen, E" sort="Widen, E" uniqKey="Widen E" first="E" last="Widen">E. Widen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff77">
<institution>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Windham, B G" sort="Windham, B G" uniqKey="Windham B" first="B G" last="Windham">B G Windham</name>
<affiliation wicri:level="1">
<nlm:aff id="aff93">
<institution>Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, MS,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Jukema, J W" sort="Jukema, J W" uniqKey="Jukema J" first="J W" last="Jukema">J W Jukema</name>
<affiliation wicri:level="1">
<nlm:aff id="aff91">
<institution>Department of Cardiology, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff94">
<institution>Durrer Center for Cardiogenetic Research</institution>
, Amsterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff95">
<institution>Interuniversity Cardiology Institute of the Netherlands</institution>
, Utrecht,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wright, A F" sort="Wright, A F" uniqKey="Wright A" first="A F" last="Wright">A F Wright</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wright, M J" sort="Wright, M J" uniqKey="Wright M" first="M J" last="Wright">M J Wright</name>
<affiliation wicri:level="1">
<nlm:aff id="aff96">
<institution>Neuroimaging Genetics Group, QIMR Berghofer Medical Research Institute</institution>
, Brisbane, QLD,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yang, Q" sort="Yang, Q" uniqKey="Yang Q" first="Q" last="Yang">Q. Yang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff31">
<institution>Department of Biostatistics, Boston University School of Public Health</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Amieva, H" sort="Amieva, H" uniqKey="Amieva H" first="H" last="Amieva">H. Amieva</name>
<affiliation wicri:level="1">
<nlm:aff id="aff52">
<institution>Inserm U897, Université Bordeaux Segalen</institution>
, Bordeaux,
<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Attia, J R" sort="Attia, J R" uniqKey="Attia J" first="J R" last="Attia">J R Attia</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">
<institution>Hunter Medical Research Institute and Faculty of Health, University of Newcastle</institution>
, Newcastle, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Bennett, D A" sort="Bennett, D A" uniqKey="Bennett D" first="D A" last="Bennett">D A Bennett</name>
<affiliation wicri:level="1">
<nlm:aff id="aff32">
<institution>Rush Alzheimer's Disease Center, Rush University Medical Center</institution>
, Chicago, IL,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Brodaty, H" sort="Brodaty, H" uniqKey="Brodaty H" first="H" last="Brodaty">H. Brodaty</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff97">
<institution>Dementia Collaborative Research Centre, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="De Craen, A J M" sort="De Craen, A J M" uniqKey="De Craen A" first="A J M" last="De Craen">A J M. De Craen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<institution>Department of Gerontology and Geriatrics, Leiden University Medical Center</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff23">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Hayward, C" sort="Hayward, C" uniqKey="Hayward C" first="C" last="Hayward">C. Hayward</name>
<affiliation wicri:level="1">
<nlm:aff id="aff29">
<institution>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ikram, M A" sort="Ikram, M A" uniqKey="Ikram M" first="M A" last="Ikram">M A Ikram</name>
<affiliation wicri:level="1">
<nlm:aff id="aff12">
<institution>Department of Neurology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff35">
<institution>Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff98">
<institution>Department of Radiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lindenberger, U" sort="Lindenberger, U" uniqKey="Lindenberger U" first="U" last="Lindenberger">U. Lindenberger</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<institution>Max Planck Institute for Human Development</institution>
, Berlin,
<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Nilsson, L G" sort="Nilsson, L G" uniqKey="Nilsson L" first="L-G" last="Nilsson">L-G Nilsson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff99">
<institution>ARC, Karolinska Institutet, Stockholm and UFBI, Umeå University</institution>
, Umeå,
<country>Sweden</country>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Porteous, D J" sort="Porteous, D J" uniqKey="Porteous D" first="D J" last="Porteous">D J Porteous</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff19">
<institution>Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff60">
<institution>Generation Scotland, University of Edinburgh Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="R Ikkonen, K" sort="R Ikkonen, K" uniqKey="R Ikkonen K" first="K" last="R Ikkönen">K. R Ikkönen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">
<institution>Institute of Behavioural Sciences, University of Helsinki</institution>
, Helsinki,
<country>Finland</country>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Reinvang, I" sort="Reinvang, I" uniqKey="Reinvang I" first="I" last="Reinvang">I. Reinvang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff57">
<institution>Department of Psychology, University of Oslo</institution>
, Oslo,
<country>Norway</country>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Rudan, I" sort="Rudan, I" uniqKey="Rudan I" first="I" last="Rudan">I. Rudan</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sachdev, P S" sort="Sachdev, P S" uniqKey="Sachdev P" first="P S" last="Sachdev">P S Sachdev</name>
<affiliation wicri:level="1">
<nlm:aff id="aff27">
<institution>Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff65">
<institution>Neuropsychiatric Institute, Prince of Wales Hospital</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schmidt, R" sort="Schmidt, R" uniqKey="Schmidt R" first="R" last="Schmidt">R. Schmidt</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<institution>Department of Neurology, Medical University of Graz</institution>
, Graz,
<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Schofield, P R" sort="Schofield, P R" uniqKey="Schofield P" first="P R" last="Schofield">P R Schofield</name>
<affiliation wicri:level="1">
<nlm:aff id="aff100">
<institution>Neuroscience Research Australia</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff101">
<institution>Faculty of Medicine, University of New South Wales</institution>
, Sydney, NSW,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Srikanth, V" sort="Srikanth, V" uniqKey="Srikanth V" first="V" last="Srikanth">V. Srikanth</name>
<affiliation>
<nlm:aff id="aff28">
<institution>Menzies Research Institute</institution>
, Hobart,
<country>Tasmania</country>
</nlm:aff>
<wicri:noCountry code="nlm country">Tasmania</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff102">
<institution>Stroke and Ageing Research, Medicine, Southern Clinical School, Monash University</institution>
, Melbourne, VIC,
<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Starr, J M" sort="Starr, J M" uniqKey="Starr J" first="J M" last="Starr">J M Starr</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff103">
<institution>Alzheimer Scotland Dementia Research Centre, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Turner, S T" sort="Turner, S T" uniqKey="Turner S" first="S T" last="Turner">S T Turner</name>
<affiliation wicri:level="1">
<nlm:aff id="aff104">
<institution>Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic</institution>
, Rochester, MN,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Weir, D R" sort="Weir, D R" uniqKey="Weir D" first="D R" last="Weir">D R Weir</name>
<affiliation wicri:level="1">
<nlm:aff id="aff58">
<institution>Survey Research Center, Institute for Social Research, University of Michigan</institution>
, Ann Arbor, MI,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Wilson, J F" sort="Wilson, J F" uniqKey="Wilson J" first="J F" last="Wilson">J F Wilson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<institution>Centre for Population Health Sciences, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Van Duijn, C" sort="Van Duijn, C" uniqKey="Van Duijn C" first="C" last="Van Duijn">C. Van Duijn</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<institution>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center</institution>
, Rotterdam,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff36">
<institution>Netherlands Consortium for Healthy Ageing</institution>
, Leiden,
<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Launer, L" sort="Launer, L" uniqKey="Launer L" first="L" last="Launer">L. Launer</name>
<affiliation wicri:level="1">
<nlm:aff id="aff63">
<institution>Intramural Research Program National Institutes on Aging, National Institutes of Health</institution>
, Bethesda, MD,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Fitzpatrick, A L" sort="Fitzpatrick, A L" uniqKey="Fitzpatrick A" first="A L" last="Fitzpatrick">A L Fitzpatrick</name>
<affiliation wicri:level="1">
<nlm:aff id="aff81">
<institution>Deparment of Epidemiology, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff105">
<institution>Department of Global Health, University of Washington</institution>
, Seattle, WA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Seshadri, S" sort="Seshadri, S" uniqKey="Seshadri S" first="S" last="Seshadri">S. Seshadri</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<institution>Department of Neurology, Boston University School of Medicine</institution>
, Boston, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff30">
<institution>Framingham Heart Study</institution>
, Framingham, MA,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Mosley, T H" sort="Mosley, T H" uniqKey="Mosley T" first="T H" last="Mosley">T H Mosley</name>
<affiliation wicri:level="1">
<nlm:aff id="aff93">
<institution>Division of Geriatrics, Department of Medicine, University of Mississippi Medical Center</institution>
, Jackson, MS,
<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Deary, I J" sort="Deary, I J" uniqKey="Deary I" first="I J" last="Deary">I J Deary</name>
<affiliation wicri:level="1">
<nlm:aff id="aff1">
<institution>Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff2">
<institution>Department of Psychology, University of Edinburgh</institution>
, Edinburgh,
<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Molecular Psychiatry</title>
<idno type="ISSN">1359-4184</idno>
<idno type="eISSN">1476-5578</idno>
<imprint>
<date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Atherosclerosis (complications)</term>
<term>Cognition (physiology)</term>
<term>Cognition Disorders (etiology)</term>
<term>Cognition Disorders (genetics)</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Genetic Predisposition to Disease (genetics)</term>
<term>Genome-Wide Association Study</term>
<term>HMGN1 Protein (genetics)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Phenotype</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Scotland</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adulte d'âge moyen</term>
<term>Athérosclérose ()</term>
<term>Cognition (physiologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Phénotype</term>
<term>Polymorphisme de nucléotide simple (génétique)</term>
<term>Protéine HMGN1 (génétique)</term>
<term>Prédisposition génétique à une maladie (génétique)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tests neuropsychologiques</term>
<term>Troubles de la cognition (génétique)</term>
<term>Troubles de la cognition (étiologie)</term>
<term>Écosse</term>
<term>Étude d'association pangénomique</term>
<term>Études de cohortes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>HMGN1 Protein</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en">
<term>Scotland</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en">
<term>Atherosclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en">
<term>Cognition Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Cognition Disorders</term>
<term>Genetic Predisposition to Disease</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Polymorphisme de nucléotide simple</term>
<term>Protéine HMGN1</term>
<term>Prédisposition génétique à une maladie</term>
<term>Troubles de la cognition</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr">
<term>Cognition</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en">
<term>Cognition</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr">
<term>Troubles de la cognition</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Genome-Wide Association Study</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Phenotype</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adulte d'âge moyen</term>
<term>Athérosclérose</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Phénotype</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tests neuropsychologiques</term>
<term>Écosse</term>
<term>Étude d'association pangénomique</term>
<term>Études de cohortes</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (
<italic>N</italic>
=53 949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441,
<italic>P</italic>
=3.93 × 10
<sup>−9</sup>
,
<italic>MIR2113</italic>
; rs17522122,
<italic>P</italic>
=2.55 × 10
<sup>−8</sup>
,
<italic>AKAP6</italic>
; rs10119,
<italic>P</italic>
=5.67 × 10
<sup>−9</sup>
,
<italic>APOE/TOMM40</italic>
). We report one gene-based significant association with the
<italic>HMGN1</italic>
gene located on chromosome 21 (
<italic>P</italic>
=1 × 10
<sup>−6</sup>
). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (
<italic>N</italic>
=6617) and the Health and Retirement Study (
<italic>N</italic>
=5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e.=5%) and 28% (s.e.=7%), respectively. Using polygenic prediction analysis, ~1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (
<italic>N</italic>
=5487;
<italic>P</italic>
=1.5 × 10
<sup>−17</sup>
). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease:
<italic>TOMM40</italic>
,
<italic>APOE</italic>
,
<italic>ABCG1</italic>
and
<italic>MEF2C</italic>
.</p>
</div>
</front>
<back>
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